Selected Publications

Brissett NC, Pitcher RS, Juarez R, Picher AJ, Green AJ, Dafforn TR, Fox GC, Blanco L* and Doherty AJ, 2007. Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science 318:456-459. (IF 26.3)


Aguilera A, Gomez-Gonzalez B, 2008. Genome instability: a mechanistic view of its causes and consequences. Nat. Rev. Genet. 9(3):204-217. (IF 24.1)

Baños B, Lázaro J M,Villar L, Salas M, de Vega M, 2008. Characterization of a Bacillus subtilis 64-kDa DNA polymerase X potentially involved in DNA repair. J. Mol. Biol. 384: 1019-1028. (IF 4.146)

Baños B, Lázaro J M,Villar L, Salas M, de Vega M, 2008. Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucl. Acids Res. 36:5736-5749. (IF 6.8)

Borlado LR, Mendez J. 2008. CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 29:237-243. (IF 4.9)

Colomina N, Ferrezuelo F, Wang H, Aldea M, Gari E. 2008. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. J Biol Chem 283: 28670-28679. (IF 5.5)

Davis, L., Rozalén, A.E., Moreno, S. , Smith, G.R. and Martín-Castellanos, C. 2008. Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination. Current Biol. 18:849-854. (IF 10.7)

García-Higuera, I., Manchado, E., Dubus, P., Cañamero, M., Méndez, J., Moreno, S. , and Malumbres, M. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nature Cell Biol 10:802-811. (IF 17.7)

Huertas P, Cortes-Ledesma F, Sartori AA, Aguilera A, Jackson SP, 2008. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455:689-692 (IF 31.4)

Ibarra, A., Schwob, E., and Méndez, J. 2008. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication. Proc Natl Acad Sci USA 105: 8956-8961. [*]

Losada A. 2008. The regulation of sister chromatid cohesion. Biochim. Biophys. Acta 1786:41-48

Pérez-Hidalgo, L., Rozalén, A.E., Martín-Castellanos, C and Moreno, S. 2008. Slk1 is a meiosis-specific Sid2-related kinase that coordinates meiotic nuclear division with growth of the forespore membrane. J. Cell Science 121:1383-1392. (IF 6.2)

Rivera, T., and Losada, A. 2009. Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts. Chromosoma 118:223-33. (IF 5.1)

Salas M, Blanco L, Lazaro JM, de Veja M. 2008. The bacteriophage phi29 DNA polymerase. IUBMB Life 60:82-85. (IF 2.3)

Serrano-Heras, G. Bravo, A. and Salas M. 2008. Phage phi29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase. Proc. Natl. Acad. Sci. 105:19044-19049. [*]

Vázquez, M. V., Rojas, V. and Tercero, J. A. 2008. Multiple pathways cooperate to facilitate DNA replication fork progression through alkylated DNA. DNA Repair 7:1693-1704. (IF 5.0)


Andrade P, Martín MJ, Juárez R, López de Saro F, Blanco L. 2009. Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Proc. Natl. Acad. Sci. 106:16203-16208.

Cambray S, Pedraza N, Rafel M, Garí E, Aldea M, Gallego C. 2009. Protein kinase KIS localizes to RNA granules and enhances local translation. Mol. Cell. Biol. 29:726-735 (IF 5.9)

Gomez-Gonzalez B, Aguilera A. 2009. R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX. Nucl. Acids Res. 37(13): 4315-4321 (IF 6.8)

Gomez-Gonzalez B, Felipe-Abrio I, Aguilera A. 2009. The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol. Cell. Biol 29(19):5203-5213 (IF 5.9)

Gozalbo-López B, Andrade P, Terrados G, de Andrés B, Serrano N, Cortegano I, Palacios B, Bernad A, Blanco L, Marcos MA, Gaspar ML. 2009. A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Mol. Cell Biol. 29:1266-1275. (IF 5.9)

Ibarra B, Chemla YR, Plyasunov S, Smith SB, Lazaro JM, Salas M, Bustamante C. 2009. Proofreading dynamics of a processive DNA polymerase. EMBO J. 28:2794-2802 (IF 8.2)

Mas G, de Nadal E, Dechant R, de la Concepción ML, Logie C, Jimeno-González S, Chávez S, Ammerer G, Posas F. 2009. Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes. EMBO J. 28:326-36. (IF 8.2)

Muños-Espin D, Daniel R, Hawai Y, Carballido-Lopz R, Castilla-Llorente V, Errington J, Meijer W, Salas M. 2009. The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria. Proc. Natl. Acad. Sci. 106(32):13347-13352

Pardo B, Gomez-Gonzalez B, Aguilera A. 2009. DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship. Cell Mol. Life Sci. 66:1039-1056 (5.5)

Ruiz J F, Gomez-Gonzalez B, Aguilera A. 2009. Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication. Mol. Cell. Biol 29(20):5441-5454 (5.9)

Segurado M, Tercero JA. 2009. The S-phase checkpoint: targeting the replication fork. Biol Cell. 101(11):617-27

Serrano A, Rodríguez-Corsino M, Losada A. 2009. Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. PLoS One 4: e5118

Tercero JA. 2009. Density transfer as a method to analyze the progression of DNA replication forks. Methods Mol Biol. 521:203-13

Terrados G, Capp J-P, Canitrot Y, García-Díaz M, Bebenek K, Kirchhoff T, Villanueva A, Boudsoq F, Bergoglio V, Cazaux C, Kunkel TA, Hoffmann JS, Blanco L. 2009. Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ. PLoS ONE 4(10): e7290. doi:10.1371/journal.pone.0007290

Yaakov G, Duch A, Garcia-Rubio M, Clotet J, Jiménez J, Aguilera A, Posas F. 2009. The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress. Mol. Biol. Cell. 20:3572-3582 (IF 5.5)


Baños, B. Villar, L. Salas, M. and de Vega, M. Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites. 2010. Proc. Natl. Acad. Sci. USA. 107, 19219-19224.

Bermúdez-López M, Ceschia A, de Piccoli G, Colomina N, Pasero P, Aragón L, and Torres-Rosell J. The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. 2010. Nucleic Acids Res. 38:6502-12.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L and Doherty AJ. Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase. 2010. Mol. Cell41:221-231.

Capp JP, Boudsocq F, Bergoglio V, Trouche D, Cazaux C, Blanco L, Hoffmann JS, and Canitrot Y. The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway. 2010. Carcinogenesis 31, 1742-1747.

Cotobal C, Segurado M and Antequera F. Structural diversity and dynamics of genomic replication origins in Schizosaccharomyces pombe. 2010. EMBO J. 29:934-42.

de Vega M, Lázaro JM, Mencía M, Blanco L, and Salas M. Improvement of f29 DNA polymerase amplification performance by fusion of DNA binding motifs. 2010. Proc. Natl. Acad. Sci. USA. 107, 16506-16511.

Ferreiro I, Joaquin M, Islam A, Gomez-Lopez G, Barragan M, Lombardía L, Domínguez O, Pisano DG, Lopez-Bigas N, Nebreda AR and Posas F. Whole genome analysis of p38 SAPK-mediated gene expression upon stress. 2010 BMC Genomics. 11:144.

Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M and Posas F. The p38 SAPK is recruited to chromatin via its interaction with transcription factors. 2010. J. Biol Chem. 285(41): 31819-28.

Ferrezuelo F, Colomina N, Futcher B and Aldea M. The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle. 2010. Genome Biol. 11:R67

Guillou, E. Ibarra, A. Coulon, V.J. Casado-Vela, J Casal, I. Schwob, E. Losada A. and Méndez, J. Cohesin organizes chromatin loops at DNA replication factories. 2010. Genes Dev. 24(24):2812-22.

Manchado, E., Guillamot, M., de Cárcer, G., Eguren, M., Trickey, M., García-Higuera, I., Moreno, S, Yamano, H, Cañamero, M, Malumbres, M. Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55a,d phosphatase. 2010 Cancer Cell 18, 641-654

Moriel-Carretero, M. and Aguilera, A. A postincision-deficient TFIIH causes replication fork breakage and uncovers alternative Rad51- or Pol32-mediated restart mechanisms. 2010. Mol. Cell 37 (5):690-701.

Muñóz-Espín, D. Holguera, I. Ballesteros-Plaza, D. Carballido-López R. and Salas M. Viral terminal protein directs early organization of phage DNA replication at the bacterial nucleoid 2010. Proc. Natl. Acad. Sci. USA. 107, 16548-16553.

Nieto, C., Almendinger, J., Gysi, S., Kaech, A., Hengartner, M., Schnabel, R., Moreno, S. and Cabello, J. ccz-1 mediates the digestion of apoptotic corpses in C. elegans. 2010. J. Cell Sci. 123, 2001-2007.

Quintales L, Sánchez M and Antequera F. Analysis of DNA strand-specific differential expression with high density tiling microarrays. 2010. BMC Bioinformatics 11: 136

Regot S, Macia J, Conde N, Peeters T, Kentaro F, Kjellen J, Hohmann, S. de Nadal, E, Posas F and Solé R. Distributed biological computation with multicellular engineered networks. 2011. Nature, DOI:10.1038/nature09679. 469(7329):207-11

Sardina JL, López-Ruano G, ... Sánchez-Yagüe J and Hernández-Hernández A. p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation. 2010. Cell Death Differ. 17:1842-54

Valbuena, N. and Moreno, S. TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast. 2010. PloS ONE 5, e11514.

Warringer J, Hult M, Regot S, Posas F and Sunnerhagen P. The HOG pathway dictates the short-term translational response after hyperosmotic shock. 2010. Mol Biol Cell. 21(17): 3080-92.


Adrover MÀ, Zi Z, Duch A, Schaber J, González-Novo A, Jimenez J, Nadal-Ribelles M, Clotet J, Klipp E, Posas, F. Time-dependant quantitive multicomponent control of the GB-S network by the stress-activated protein kinase Hog1 upon osmostress. 2011. Sci. Signal. 4(192):ra63

Asensio, J.L. Pérez-Lago, L. Lázaro, J.M. González, C. Serrano-Heras, G. Salas, M. Novel dimeric structure of phage ø29-encoded protein p56: Insights into uracil-DNA glycosylase inhibiton. 2011. Nucl.Acids Res. 39(22):9779-9788.

Bermejo, R. Capra, T. Jossen, R. Colosio, A. Frattini, C. Carotenuto, W. Cocito, A. Doksani, Y. Klein, H. Gomez-Gonzalez, B. Aguilera, A. Katou, Y. Shirahige, K. Foiani, M. The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores. 2011. Cell. 146:233-246

Bernad R, Sánchez P, Rivera T, Rodríguez-Corsino M, Boyarchuk E, Vassias I, Ray-Gallet D, Arnaoutov A, Dasso M, Almouzni G, Losada A. Xenopus HJURP and condensin II are required for CENP-A assembly. 2011. J Cell Biol. 192: 569-82.

Brissett NC, Martin MJ, Pitcher RS, Bianchi J, Juarez R, Green AJ, Fox GC, Blanco L, Doherty AJ. Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. 2011. Mol Cell. 41(2):221-31.

Bonfils, S.G.O., Rozalén, A.E., Smith, G.R., Moreno, S. and Martín-Castellanos, C. Functional Interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex. 2011. Journal of Cell Science 124, 1328-1338.

De Castro, E., Soriano, I., Marín, L., Serrano, R., Quintales, L. Antequera, F. Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast. 2011. EMBO J. 31, 124–137

de la Loza, M.C.D. Gallardo, M. Garcia-Rubio, ML. Izquierdo, A. Herrero, E. Aguilera, A. Wellinger, R. Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability. 2011. Nucleic Acids Res. 8:620-626.

de Vega, M. Salas, M. Protein-primed replication of bacteriophage ø29 DNA. DNA Replication/Book. Ed. By Jelena Kusic. 2011. INTECH. ISBN 978-953-307-775-8.

Domínguez-Kelly R, Martín Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. 2011. J Cell Biol. 194 (4):567-79.

Dominguez-Sanchez MS, Saez, C. Japon, MA. Aguilera, A. Luna, R. Differential expression of THOC1 and ALLY mRNP biogenesis/export factors in human cancers. 2011. BMC Cancer 11:77.

Domínguez-Sanchez MS, Barroso S, Gomez-Gonzalez B, Luna R, Aguilera A. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. 2011. PLoS Genetics. 7(12):e1002386.

Fernández RMH, Ruiz-Miró M, Dolcet X, Aldea M, Garí E. Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility. 2011. Oncogene 30: 1936-1946.

Garcia-Rubio ML, Aguilera A. Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. 2011. Nucleic Acids Res. 40(3):1050-64

Gomez-Gonzalez, B. Garcia-Rubio, M. Bermejo, R. Gaillard, H. Shirahige, K. Marin, A. Foiani, M. Aguilera, A. Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. 2011. EMBO J. 30(15):3106-3119.

Herrero, A.B. and Moreno, S. Lsm1 promotes genomic stability by controlling histone mRNA decay. 2011. EMBO J. 30:2008-2018

Hohl, M. Kwon, Y. Muñoz Galvan, S. Xue, X. Tous, C. Aguilera, A.P. Sung, P. Petrini, J.H.J. The Rad50 coiled-coil domain is indispensable for Mre11 complex functions. 2011. Nat. Struct. Mol. Biol. 18(10):1124-1131

Holt, J.A., Tran, S.M.T., Stewart, J.L., Minahan, K., García-Higuera, I., Moreno, S. and Jones, K.T. The APC/C activator FZR1 co-ordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. 2011. Development 138, 905-913

Mischo. H:E., Gómez-González, B., Grzechnik, P., Rondón, A.G., Wei, W, Steinmetz, L., Aguilera, A.* and Proudfoot, N.J.*. Yeast Sen1 helicase protects the genome from transcription-associated instability. 2011. Mol. Cell 41 (1): 1-12 (*corresponding authors)

Moriel-Carretero M, Tous C, Aguilera A. Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1. 2011. Proc. Natl. Acad. Sci. USA. 108:15300-5

Neukomm, L.J., Andreas P., Frei, A.P., Cabello, J., Ma, X., Haney, L.B., Ravichandran, K.S., Moreno, S. and Hengartner, M.O. RhoGAP SRGP-1 promotes survival and antagonizes clearance of apoptotic cells in C. elegans. 2011. Nature Cell Biology 13, 79-86.

Pérez-Lago, L. Serrano-Heras, G. Baños, B. Lázaro, J.M. Alcorlo, M. Villar, L. and Salas, M. Characterization of /Bacillus subtilis/ Uracil-DNA glycosylase and its inhibition by phage ø29 protein p56. Mol. 2011. Microbiol. 80:1657-1666

Regot S, Macia J, Conde N, Furukawa K, Kjellén J, Peeters T, Hohmann S, de Nadal E, Posas F, Solé R. Distributed biological computation with multicellular engineered networks. 2011. Nature. 469(7329):207-11.

Ruiz, J.F. Gomez-Gonzalez, B. Aguilera A. AID induced double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants. 2011. PLos Genetics 7(2): e1002009

Ruiz-Miró M, Colomina N, Fernández RMH, Garí E, Gallego C, Aldea M. Translokin interacts with cyclin D1 and prevents its nuclear accumulation in quiescent cells. 2011. Traffic 12: 549-562

Sanchez, P. Losada, A. New clues to understand how CENP-A maintains centromere identity. 2011. Cell Division 6:11

Sanchez-Berrondo J, Mesa P, Ibarra A, Martínez-Jiménez MI, Blanco L, Méndez J, Boskovic J, Montoya G. 2011. Molecular architecture of a multifunctional MCM complex. Nucleic Acids Res. 40(3):1366-80. doi: 10.1093/nar/gkr831.

Sardina, J.L., López-Ruano, G., Sánchez-Sánchez, B., Llanillo, M., Hernández-Hernández, A. Reactive oxygen species: Are they important for haematopoiesis? 2011. Crit Rev Oncol Hematol. 81(3):257-74

Torres-Rosell J, Losada A. Smc5 flies solo. 2011. Cell Cycle 10: 879-8.

Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. 2011. EMBO Rep. doi: 10.1038/embor.2011.154.

Zaratiegui, M., Castel, S., Irvine, D., Kloc, A., Ren, J., Li, F., de Castro, E., Marín, L., Chang, A., Goto, D., Cande, Z., Antequera, F., Arcangioli B. Martienssen, R. RNAi promotes heterochromatic silencing through replication-coupled release of RNA pol II. 2011. Nature. 479(7371):135-8


Aguilera A, García-Muse T. 2012. R Loops: From Transcription Byproducts to Threats to Genome Stability. Mol. Cell 46:115-124

Almedawar S, Colomina N, Bermúdez-López M, Pociño-Merino I, Torres-Rosell J. 2012. A SUMO-Dependent Step during Establishment of Sister Chromatid Cohesion Curr Biol. 22(17):1576-81

Aparicio T, Megías D, Méndez J. 2012. Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis. Chromosoma. 121(5):499-507

Asensio-Juan E, Gallego C, Martínez-Balbás MA. 2012. The histone demethylase PHF8 is essential for cytoskeleton dynamics. Nucleic Acids Research 40(19):9429-40

Baños B, Villar L, Salas M, de Vega M. 2012. DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. Nucleic Acids Res. 40(19):9750-62

Caron P, Aymard F, Iacovoni JS, Briois S, Canitrot Y, Bugler B, Massip L, Losada A, Legube G. 2012. Cohesin protects genes against ?H2AX Induced by DNA double-strand breaks. PLoS Genet. 8(1):e1002460

Castellano-Pozo M, García-Muse T, Aguilera A.. 2012. R-loops cause replication impairment and genome instability during meiosis. EMBO Rep. 13: 923-929

Castellano-Pozo M, García-Muse T, Aguilera A. 2012. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. PLoS One 7(12):e52447

Cuadrado A, Remeseiro S, Gómez-López G, Pisano DG, Losada A. 2012. The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development. Cell Cycle. 11(12):2233-8

Duch A, de Nadal E, Posas F. 2012. The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses. FEBS Lett. 586(18):2925-31

Ferrezuelo F, Colomina N, Palmisano A, Garí E, Gallego C, Csikász-Nagy A, Aldea M. 2012. The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation. Nat Común 3:1012

Gaillard H, Aguilera A. 2012. Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis. Biochim Biophys Acta. 1829(1):141-50

Gallo-Fernández, M., Saugar, I., Ortiz-Bazán, M. A., Vázquez, M. V. and Tercero, J. A. 2012. Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res. 40(17):8325-8335

García-Rubio ML, Aguilera A. 2012. Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes. Nucleic Acids Res. 40:1050-1064

Hauser, R. Blasche, S. Dokland, T. Haggard-Ljungquist, E. von Brunn, A. Salas, M. Casjens, S. Molineux, I and Uetz, P. 2012. Bacteriophage protein-protein interactions. Advances in Virus Research, Part B. Vol. 83, Burlington:AcademicPress, 219-98

Holguera I, Ballesteros-Plaza D, Muñoz-Espín D, Salas M. 2012. Disclosing the in vivo organization of a viral histone-like protein in Bacillus subtilis mediated by its capacity to recognize the viral genome. Proc Natl Acad Sci U S A. 109(15):5723-8

Holt, J.E., Lane S.I.R., Jennings, P., García-Higuera, I., Moreno, S. and Jones, K.T. 2012. APC(FZR1) prevents non-disjunction in mouse oocytes by controlling meiotic spindle assembly timing. Molecular Biology of the Cell 23:3970-3981.

Joaquin M, Gubern A, González-Nuñez D, Josué Ruiz E, Ferreiro I, de Nadal E, Nebreda AR, Posas F. 2012. The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J. 2012 31(13):2952-64

Joaquin M, Gubern A, Posas F. 2012. A novel G1 checkpoint mediated by the p57 CDK inhibitor and p38 SAPK promotes cell survival upon stress. Cell Cycle 11(18):3339-40.

Luna R, Rondón AG, Aguilera A. 2012. New clues to understand the role of THO and other functionally related factors in mRNP biogenesis. Biochim. Biophys. Acta 1819:514-520

Martin MJ, Juarez R, and Blanco L. 2012. DNA binding determinants promoting NHEJ by human Polµ. Nucleic Acids Research 40:11389-11403.

Mendieta, J. Pérez-Lago, L. Salas, M. and Camacho, A. 2012. Functional specificity of a protein-DNA complex mediated by two arginines bound to the minor groove. J. Bacteriol. 194:4727-4735.

Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B. 2012. Active DNA unwinding dynamics during processive DNA replication. Proc Natl Acad Sci U S A. 109(21):8115-20

Muñoz-Espín D, Serrano-Heras G, Salas M. 2012 Role of host factors in bacteriophage f29 DNA replication. Adv Virus Res. 82:351-83.

Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A. 2012. Distinct roles of Mus81, Yen1, Slx1-Slx4 and Rad1 nucleases in the repair of replication-born double strand breaks by sister chromatid exchange. Mol. Cell. Biol. 32:1592-1603

Nadal-Ribelles M, Conde N, Flores O, González-Vallinas J, Eyras E, Orozco M, de Nadal E, Posas F. 2012. Hog1 bypasses stress-mediated down-regulation of transcription by RNA polymerase II redistribution and chromatin remodeling. Genome Biol. 13(11):R106.

Pardo B, Aguilera A. 2012. Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases. PLoS Genet. 8(9): e1002979

Pérez-Castro AJ, Freire R. 2012 Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition. J Cell Sci. 125(Pt 5):1152-64

Pérez-Hidalgo, L. and Moreno, S. 2012. Chemical inactivation of Pat1: a novel approach to synchronize meiosis.CellCycle11:1875

Redrejo-Rodríguez, M. Muñoz-Espín, D. Holguera, I. Mencía, M. and Salas, M. 2012. Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages. Proc.Natl.Acad.Sci.USA 109:18482-18487.

Remeseiro S, Cuadrado A, Carretero M, Martínez P, Drosopoulos WC, Cañamero M, Schildkraut CL, Blasco MA, Losada A ( 2012). Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J 31:2076-2089.

Remeseiro S, Cuadrado A, Gómez-López G, Pisano DG, Losada A ( 2012). A unique role of cohesin-SA1 in gene regulation and development. EMBO J 31:2090-2102.

Rivera T, Ghenoiu C, Rodríguez-Corsino M, Mochida S, Funabiki H, Losada A. ( 2012). Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO J. 31:1467-1479

Rodríguez, I. Longás, E. de Vega, M.and Salas, M . 2012. The essential role of the 3´ terminal template base in the first steps of protein-primed DNA replication. PLoS ONE. 7:48257.

Saito H, Posas F. 2012. Response to hyperosmotic stress. Genetics 192(2):289-318.

Seah, M. K.Y., Holt, J., García-Higuera, I., Moreno, S. and Jones, K. T. 2012. The Anaphase-Promoting Complex activator Fizzy-Related-1 (FZR1) is involved in the establishment of a single mitotic spindle in 1-cell embryos and in the mitotic divisions of early mammalian embryos. Journal of Cell Science 125:6030-6037.

Valbuena, N., Guan K.-L. and Moreno, S. 2012. The Vam6-Gtr1/Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Journal of Cell Science 125:1920-1928.

Valbuena, N. and Moreno, S. 2012. AMPK phosphorylation by Ssp1 is required for proper sexual differentiation in fission yeast. Journal of Cell Science 125:2655-2664.

Valbuena, N., Rozalén, A.E. and Moreno, S. 2012. Fission yeast TORC1 prevents eIF2a phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. Journal of Cell Science 125:5955-5959.


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Bermúdez-López M, Villoria MT, Esteras M, Jarmuz A, Torres-Rosell J, Clemente-Blanco A, Aragon L. Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6. Genes Dev. 30(11):1339-56.

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Chica N, Rozalén AE, Pérez-Hidalgo L, Rubio A, Novak B, Moreno S. Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A-B55 Pathway. Curr Biol. 26(3):319-30.

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Fernández-Orgiler A, Martínez-Jiménez MI, Alonso A, Alcolea PJ, Requena JM, Thomas MC, Blanco L, Larraga V. A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage. Nucleic Acids Res. 44(10):4855-70.

Fusté NP, Fernández-Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, Torres-Rosell J, Colomina N, Ferrezuelo F, Dolcet X, Garí E.Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin. Nat Commun. 7:11581.

Gaillard H, Aguilera A. Transcription as a Threat to Genome Integrity.Annu Rev Biochem. 85:291-317.

García-Muse T, Aguilera A. Transcription-replication conflicts: how they occur and how they are resolved. Nat Rev Mol Cell Biol. 17(9):553-63.

Gavaldá S, Santos-Pereira JM, García-Rubio ML, Luna R, Aguilera A. Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening. PLoS Genet. 12(4):e1005966.

Gella P, Salas M, Mencía M. Engineering permissive insertion sites in the bacteriophage Phi29 DNA-linked terminal protein. Enviado a PLoS One. 11(10):e0164901

Gómez R, Felipe-Medina N, Ruiz-Torres M, Berenguer I, Viera A, Pérez S, Barbero JL, Llano E, Fukuda T, Alsheimer M, Pendás AM, Losada A, Suja JA. Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes. EMBO Rep 17(5):695-707.

González S, García A, Vázquez E, Serrano R, Sánchez M, Quintales L, Antequera F. Nucleosomal signatures impose nucleosome positioning in coding and non-coding sequences in the genome. Genome Research 26(11):1532-1543

Gubern A, Joaquin M, Marquès M, Maseres P, Garcia-Garcia J, Amat R, González-Nuñez D, Oliva B, Real FX, de Nadal E, Posas F. The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. Mol Cell. 64(1):25-36.

Hernández-Pérez S, Cabrera E, Amoedo H, Rodríguez-Acebes S, Koundrioukoff S, Debatisse M, Méndez J, Freire R. USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication. Mol Oncol. pii: S1574-7891(16)30044-8.

Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 23(4):270-7.

Macia J, Manzoni R, Conde N, Urrios A, de Nadal E, Solé R, Posas F. Implementation of complex biological logic circuits using spatially distributed multicellular consortia. PLOS Comput. Biol. 12(2):e1004685.

Madireddy A, Kosiyatrakul ST, Boisvert RA, Herrera-Moyano E, García-Rubio ML, Gerhardt J, Vuono EA, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL. FANCD2 Facilitates Replication through Common Fragile Sites. Mol Cell. 64(2):388-404.

Manzoni R, Urrios A, Velazquez-Garcia S, de Nadal E, Posas F. Synthetic biology: insights into digital computation. Integr Biol (Camb). 8(4):518-532

Materne P, Vázquez E, Sánchez M, Yague-Sanz C, Anandhakumar J, Migeot V, Antequera F & Hermand D. Histone H2B ubiquitylation repressesd gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. eLIFE 5: e13500 (doi: 10.7554/eLife.13500)

Mojardín L, Salas M. Global transcriptional analysis of virus-host interactions between phage 29 and Bacillus subtilis. J. Virol. 90, 9293-9304.

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Pérez-Hidalgo L, Moreno S. utrients control cell size. Cell Cycle. Apr 8:1-2.

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Studer RA, Rodriguez-Mias RA, Haas KM, Hsu JI, Viéitez C, Solé C, Swaney DL, Stanford LB, Liachko I, Böttcher R, Dunham MJ, de Nadal E, Posas F, Beltrao P, Villén J. Evolution of protein phosphorylation across 18 fungal species. Science. 354(6309):229-232.

Tormos-Pérez M, Pérez-Hidalgo L, Moreno S. Fission Yeast Cell Cycle Synchronization Methods. Methods Mol Biol. 1369:293-308.

Tumini E, Barroso S, -Calero CP, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 6:38873.

Urrios A, Macia J, Manzoni R, Conde N, Bonforti A, de Nadal E, Posas F, Sole R. A synthetic multicellular memory device. ACS Synth Biol. 19;5(8):862-73.

Urrios A, Parra-Cabrera C, Bhattacharjee N, Gonzalez-Suarez AM, Rigat-Brugarolas LG, Nallapatti U, Samitier J, DeForest CA, Posas F, Garcia-Cordero JL, Folch A.3D-printing of transparent bio-microfluidic devices in PEG-DA. Lab Chip. 16(12):2287-94

Williams SJ, Abrieu A, Losada A.Bub1 targeting to centromeres is sufficient for Sgo1 recruitment in the absence of kinetochores. Chromosoma. 2016 Apr 26. [Epub ahead of print]

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Agudo R, Calvo PA, Martínez-Jiménez MI, Blanco L. Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase. Nucleic Acids Res. 45(15):9046-9058.

Aguilera A, Gómez-González B. DNA-RNA hybrids: the risks of DNA breakage during transcription. Nat Struct Mol Biol. 24(5):439-443.

Aldea M, Jenkins K, Csikász-Nagy A. Growth Rate as a Direct Regulator of the Start Network to Set Cell Size. Front Cell Dev Biol. 5:57

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Berjón-Otero M, Lechuga A, Mehla J, Uetz P, Salas M, Redrejo-Rodríguez M. Bam35 tectivirus intraviral interaction map unveils new function and localization of phage ORFan proteins. J. Virol. 91,00870-17.

Bhatia V, Herrera-Moyano E, Aguilera A, Gómez-González B. The Role of Replication-Associated Repair Factors on R-Loops. Genes (Basel). 8(7). pii: E171.

Brun S, Abella N, Berciano MT, Tapia O, Jaumot M, Freire R, Lafarga M, Agell N. SUMO Regulates p21Cip1 Intracellular Distribution and with p21Cip1 Facilitates Multiprotein Complex Formation in the Nucleolus upon DNA Damage. Plos One. 12, pp. e0178925.

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Chang YL, Tseng SF, Huang YC, Shen ZJ, Hsu PH, Hsieh MH, Yang CW, Tognetti S, Canal B, Subirana L, Wang CW, Chen HT, Lin CY, Posas F, Teng SC. Yeast Cip1 is activated by environmental stress to inhibit Cdk1-G1 cyclins via Mcm1 and Msn2/4. Nat Commun. 8: 56.

Colomina N, Guasch C, Torres-Rosell J. Analysis of SUMOylation in the RENT Complex by Fusion to a SUMO-Specific Protease Domain. Methods Mol Biol 1505:97-117.

Escudero B, Herrero D, Torres Y, Cañón S, Molina A, Carmona RM, Suela J, Blanco L, Samper E, Bernad A. Polµ deficiency induces moderate shortening of P53-/- mouse lifespan and modifies tumor spectrum. DNA Repair (Amst) 54:40-45. doi: 10.1016/j.dnarep.2017.04.001.

García A, González S, Antequera F. Nucleosomal organization and DNA base composition patterns. Nucleus 8: 469-474

García-Benítez F, Gaillard H, Aguilera A. Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability. Proc Natl Acad Sci U S A. 114(41):10942-10947.

García-Pichardo D, Cañas JC, García-Rubio ML, Gómez-González B, Rondón AG, Aguilera A. Histone Mutants Separate R Loop Formation from Genome Instability Induction. Mol Cell. 66(5):597-609.e5.

García-Rubio M, Barroso SI, Aguilera A. Detection of DNA-RNA Hybrids In Vivo. Methods Mol Biol. 1672:347-361.

Gómez-González B, Aguilera A. The need to regulate replication fork speed. Science. 10;358(6364):722-723.

Hernández-Pérez S, Cabrera E, Salido E, Lim M, Reid L, Lakhani SR, Khanna KK, Saunus JM, Freire R. DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer Oncogene. 36, 4802-4809.

Jimeno S, Herrera-Moyano E, Ortega P, Aguilera A. Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells. DNA Repair (Amst). 57:66-75.

Lafuente-Barquero J, Luke-Glaser S, Graf M, Silva S, Gómez-González B, Lockhart A, Lisby M, Aguilera A, Luke B. The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage. PLoS Genet. 13(12):e1007136.

Lahoz F, Martin IR, Walo D, Freire R, Gil-Rostra J, Yubero F, Gonzalez-Elipe AR. Enhanced green fluorescent protein in optofluidic Fabry-Perot microcavity to detect laser induced temperature changes in a bacterial culture. Appled Physics Letters. 111, 111103.

Linke C, Chasapi A, González-Novo A, Al Sawad I, Tognetti S, Klipp E, Loog M, Krobitsch S, Posas F, Xenarios I, Barberis M. A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle. NPJ Syst Biol Appl. 6: 7.

Liu Y, Cussiol JR, Dibitetto D, Sims JR, Twayana S, Weiss RS, Freire R, Marini F, Pellicioli A, Smolka MB. TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol.216, pp.623-639.

Martínez-Jiménez MI, Lahera A, Blanco L. Human PrimPol activity is enhanced by RPA. Sci Rep. 7(1):783. doi: 10.1038/s41598-017-00958-3.

Martins TS, Pereira C, Canadell D, Vilaça R, Teixeira V, Moradas-Ferreira P, de Nadal E, Posas F, Costa V. The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation. Biochim Biophys Acta. 1863:61-70.

Muñoz S, Búa S, Rodríguez-Acebes S, Megías D, Ortega S, de Martino A, Méndez J. In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias. Cell Rep. 19(5):928-938.

Muñoz-Galván S, García-Rubio M, Ortega P, Ruiz JF, Jimeno S, Pardo B, Gómez-González B, Aguilera A. A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination. PLoS Genet. 13(5):e1006781.

Pérez-Hidalgo L, Moreno S. Coupling TOR to the Cell Cycle by the Greatwall-Endosulfine-PP2A-B55 Pathway. Biomolecules. 7(3). pii: E59

Redrejo-Rodríguez M, Ordóñez CD, Berjón-Otero M, Moreno-González J, Aparicio-Maldonado C, Forterre P, Salas M, Krupovic M. Primer-independent DNA synthesis by a family B DNA polymerase from novel self- replicating genetic elements. Cell Rep. 21, 1574-1587.

Rodríguez-González M, Kawasaki-Watanabe L, Velázquez-Zavala N, Domínguez-Martín E, Trejo-Medecigo A, Martagón N, Vázquez-Ibarra A, Ongay-Larios L, Georgellis D, de Nadal E, Posas F, Coria R. Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast. Molecular Microbiology 104: 822-36.

Saarikangas J, Caudron F, Prasad R, Moreno DF, Bolognesi A, Aldea M, Barral Y. Compartmentalization of ER-Bound Chaperone Confines Protein Deposit Formation to the Aging Yeast Cell. Curr Biol. 27:773-783

Salas-Armenteros I, Pérez-Calero C, Bayona-Feliu A, Tumini E, Luna R, Aguilera A. Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. EMBO J. 36(23):3532-3547.

Sastre-Moreno G, Pryor JM, Díaz-Talavera A, Ruiz JF, Ramsden DA, Blanco L. Polµ tumor variants decrease the efficiency and accuracy of NHEJ. Nucleic Acids Res. 45(17):10018-10031.

Sastre-Moreno G, Pryor JM, Moreno-Oñate M, Herrero-Ruiz AM, Cortés-Ledesma F, Blanco L, Ramsden DA, Ruiz JF. Regulation of human pol? by ATM-mediated phosphorylation during non-homologous end joining. DNA Repair (Amst). 51:31-45. doi: 10.1016/j.dnarep.2017.01.004.

Saugar I, Jiménez-Martín A, Tercero JA. Subnuclear relocalization of structure-specific endonucleases in response to DNA damage. Cell Rep. 20: 1553-1562.

Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E. Regulation of transcription elongation in response to osmostress. PLoS Genet. 13: e1007090

Stojanovski K, Ferrar T, Benisty H, Uschner F, Delgado J, Jimenez J, Solé C, de Nadal E, Klipp E, Posas F, Serrano L, Kiel C. Interaction dynamics determine signaling and output pathway responses. Cell Reports 19: 136-49.

Torregrosa-Muñumer R, Forslund JME, Goffart S, Pfeiffer A, Stojkovic G, Carvalho G, Al-Furoukh N, Blanco L, Wanrooij S, Pohjoismäki JLO. PrimPol is required for replication reinitiation after mtDNA damage. Proc Natl Acad Sci U S A. 114(43):11398-11403.

Vonk JJ; Yeshaw WM; Pinto F; Faber AI; Lahaye LL; Kanon B; van der Zwaag M; Velayos-Baeza A; Freire R; van IJzendoorn SC; Grzeschik NA; Sibon OC. Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.PLoS One. 12, pp. e0170106.

Yague-Sanz C, Vázquez E, Sánchez M, Antequera F, Hermand D. A conserved role of the RSC chromatin remodeler in the establishment of nucleosome depleted regions. Current Genet 63: 187-193


Aymoz D, Solé C, Pierre JJ, Schmitt M, de Nadal E, Posas F, Pelet S. Timing of gene expression in a cell-fate decision system. Mol Syst Biol. Apr 25;14(4):e8024

Canal B, Duch A, Posas F, de Nadal E. A novel mechanism for the prevention of transcription replication conflicts. Mol Cell Oncol. 5(3) :e1451233

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A et al. Guidelines and recommendations on yeast cell death nomenclature. Microb Cell. 5(1):4-31

Cortés JC, Ramos M, Konomi M, Barragán I, Moreno MB, Alcaide-Gavilán M, Moreno S, Osumi M, Pérez P, Ribas JC. Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion. PLoS Genetics 14, e10073388.

Cubiles MD, Barroso S, Vaquero-Sedas MI, Enguix A, Aguilera A, Vega-Palas MA. Epigenetic features of human telomeres. Nucleic Acids Res. 46(5):2347-2355

Del Prado A, Franco-Echevarría E, González B, Blanco L, Salas M, de Vega M. Noncatalytic aspartate at the exonuclease domain of proofreading DNA polymerases regulates both degradative and synthetic activities. Proc.Natl.Acad.Sci.USA. 115, 2921-2929.

Duch A, Canal B, Barroso SI, García-Rubio M, Seisenbacher G, Aguilera A, de Nadal E, Posas F. Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts. Nat Commun 9(1):379

Fornelos N, Browning DF, Pavlin A, Podlesek Z, Hodnik V, Salas M, Butala M. Lytic gene expression in the temperature bacteriophage GIL01 is activated by a phage-encoded LexA homologue. Nucleic Acids Res. Doi: 10.1093.

Gaillard H, García-Benítez F, Aguilera A. Gene gating at nuclear pores prevents the formation of R loops. Mol Cell Oncol. 5(1):e1405140

García-Rubio M, Barroso SI, Aguilera A. Detection of DNA-RNA Hybrids In Vivo. Methods Mol Biol 1672:347-361

García-Rubio M, Aguilera P, Lafuente-Barquero J, Ruiz JF, Simon MN, Geli V, Rondón AG, Aguilera A. Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability. Genes Dev. 32(13-14):965-977

Gong EY, Hernández B, Nielsen JH, Smits VAJ, Freire R, Gillespie DA. Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation. Sci Rep. 8(1):17536. doi: 10.1038/s41598-018-35616-9.

Hernández-Carralero E, Cabrera E, Alonso-de Vega I, Hernández-Pérez S, Smits VAJ, Freire R. Control of DNA Replication Initiation by Ubiquitin. Cells. 7(10). pii: E146. doi: 10.3390/cells7100146.

Kim D, Liu Y, Oberly S, Freire R, Smolka MB. ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells. Nucleic Acids Res. doi: 10.1093/nar/gky625.

Kojic A, Cuadrado A, De Koninck M, Giménez-Llorente D, Rodríguez-Corsino M, Gómez-López G, Le Dily F Marti-Renom MA, Losada A Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D genome organization. Nat Struct Mol Biol 25,496-504.

Lechuga A, Berjón-Otero M, Redrejo-Rodríguez M, Salas M. Analysis of direct interation between viral DNA binding proteins by protein pull-down co-immunoprecipitation assay. Bio-protocol. Vol. 8.

Martinez-Jimenez MI, Calvo PA, Garcia-Gomez S, Guerra-Gonzalez S, Blanco L. The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming. Nucleic acids research, 46, 4138-4151.

Martínez-Láinez JM, Moreno DF, Parisi E, Clotet J, Aldea M Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast. PLoS Biol 16(8):e2005388

Morales C, Losada A Establishing and dissolving cohesion during the vertebrate cell cycle. Curr Op Cell Biol 25, 496-504.

Moreno DF, Aldea M Coincidence analysis of molecular dynamics by Raster Image Correlation Spectroscopy. Methods Mol Biol 2040: 375-84

Parisi E, Yahya G, Flores A, Aldea M Cdc48/p97 segregase is modulated by Cdk to determine cyclin fate during G1 progression. EMBO J 37(16):e98724

Pérez-Olivares M, Trento A, Rodriguez-Acebes S, González-Acosta D, Fernández-Antorán D, Román-García S, Martinez D, López-Briones T, Torroja C, Carrasco YR, Méndez J, Moreno de Alborán I Functional interplay between c-Myc and Max in B lymphocyte differentiation. EMBO Rep 19, e45770.

Rodriguez-Acebes S, Mourón S, Méndez J Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes. J Biol Chem 293, 12855-12861.

Rubio A, García-Blanco N, Vázquez-Bolado A, Suárez MB, Moreno S. Nutritional cell cycle reprogramming reveals that inhibition of Cdk1is required for proper MBF-dependent transcription. Journal of Cell Science 131, jcs218743. Doi:101242/jcs218743.

Sertic S, Mollica A, Campus I, Roma S, Tumini E, Aguilera A, Muzi-Falconi M. Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions. Mol Cell. 70(1):189

Silva S, Camino LP, Aguilera A. Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability. Proc Natl Acad Sci U S A. 115 (43):11024-11029

Smits VAJ, Cabrera E, Freire R, Gillespie DA. Claspin - checkpoint adaptor and DNA replication factor. FEBS J. doi: 10.1111/febs.14594.

Urrios A, Gonzalez-Flo E, Canadell D, de Nadal E, Macia J, Posas F. Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses. ACS Synth Biol. Apr 20;7(4):1095-1104

Van Nies P, Westerlaken I, Blanken D, Salas M, Mencía M, Danelon C. Self-replication of DNA by its encoded proteins in liposome-based synthetic cells. Nature Communications. 9, 1583.

Varejão N, Ibars E, Lascorz J, Colomina N, Torres-Rosell J, Reverter D. DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex. EMBO J. doi: 10.15252/embj.201798306.

Vázquez-Ibarra A, Subirana L, Ongay-Larios L, Kawasaki L, Rojas-Ortega E, Rodríguez-González M, de Nadal E, Posas F, Coria R. Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae. FEBS J. Mar;285(6):1079-1096

Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH. Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway. Cancer Res. Jun 1;78(11):2911-2924


Amat R, Böttcher R, Le Dily F, Vidal E, Quilez J, Cuartero Y, Beato M, de Nadal E, Posas F. Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock. Genome Res. 29(1):18-28

Barroso S, Herrera-Moyano E, Muñoz S, García-Rubio M, Gómez-González B, Aguilera A. The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins. EMBO Rep. 20(9):e47250.

Blanco L, Calvo PA, Diaz-Talavera A, Carvalho G, Calero N, Martínez-Carrón A, Velázquez-Ruiz C, Villadangos S, Guerra S, Martínez-Jiménez MI. Mechanism of DNA primer synthesis by human PrimPol. Enzymes 45, 289-310. Review.

Cabrera E, Raninga P, Khanna KK, Freire R. GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival Cancers (Basel). 11(8). pii: E1073. doi: 10.3390/cancers11081073.

Calvo PA, Sastre-Moreno G, Perpiñá C, Guerra S, Martínez-Jiménez MI, Blanco L. The invariant glutamate of human PrimPol DxE motif is critical for its Mn2+-dependent distinctive activities. DNA Repair (Amst.), 77, 65-75.

Carbonell C, Ulsamer A, Vivori C, Papasaikas P, Böttcher R, Joaquin M, Miñana B, Tejedor JR, de Nadal E, Valcárcel J, Posas F. Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK. Cell Rep. 27(3):847-859.e6.

Cuadrado A, Giménez-Llorente D, Kojic A, Rodríguez-Corsino M, Cuartero Y, Martin-Serrano G, Gómez-López G, Marti-Renom MA, Losada A Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D genome organization. Cell Rep 27, 3500-3510.

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Del Prado A, Rodríguez I, Lázaro JM, Moreno-Morcillo M, de Vega M, Salas M. New insights into the coordination between the polymerization and 3'-5' exonuclease activities in ϕ29 DNA polymerase. Sci Rep. 9(1):923.

Del Prado A, Santos E, Lázaro JM, Salas M, de Vega M. The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site. Biomolecules. 9(11). pii: E648.

Díaz-Talavera A, Calvo PA, González-Acosta D, Díaz M, Sastre-Moreno G, Blanco-Franco L, Guerra S, Martínez-Jiménez MI, Méndez J, Blanco L. A cancer-associated point mutation disbles the steric gate of human PrimPol. Scientific Reports, 9(1):1121.

Gaillard H, Santos-Pereira JM, Aguilera A. The Nup84 complex coordinates the DNA damage response to warrant genome integrity. Nucleic Acids Res. 47(8):4054-4067

García J, Lazar-Stefanita L, Gutierrez-Escribano P, Thierry A, García A, González S, Sánchez M , Jarmuz A, Montoya A, Dore M, Kramer H, Mehdi Karimi M, Antequera F, Koszul R, Aragón L. FACT mediates cohesin function on chromatin. Nature Struct. Mol. Biol. 26: 970-979

García-Blanco, N. and Moreno, S. Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication. Current Genetics 65, 685-690.

García-Blanco, N., Vázquez-Bolado, A. and Moreno, S. Greatwall-Endosulfine: a molecular switch that regulates PP2A/B55 protein phosphatase activity in dividing and quiescent cells.International Journal of Molecular Sciences 20, 6228.

Garcia-Muse T, Galindo-Diaz U, Garcia-Rubio M, Martin JS, Polanowska J, O'Reilly N, Aguilera A, Boulton SJ. A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs. Cell Rep. 26(3):775-787

García-Muse T, Aguilera A. R Loops: From Physiological to Pathological Roles. Cell 179(3):604-618

Gómez-González B, Aguilera A. Transcription-mediated replication hindrance: a major driver of genome instability. Genes Dev. 33(15-16):1008-1026

Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, Polleys EJ, Putnam CD, Radchenko EA, Saada AA, Sakofsky CJ, Shim EY, Stracy M, Xia J, Yan Z, Yin Y, Aguilera A, et al. Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways. Microb Cell. 6(1):1-64

Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, López-Contreras A, Gruss OJ, Erhardt S, Méndez J, Fernández-Capetillo O, Stoecklin G TIAR controls mitotic entry, maintains genome stability and retains CDK1 in checkpoint bodies. EMBO Rep 20, e46224 (online 11.12.2018). [Comment: Altmeyer M (2019). Cells take a break when they are TIARed. EMBO Rep 20, e47403

Moreno DF, Jenkins K, Morlot S, Charvin G, Csikasz-Nagy A, Aldea M Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1. eLife 8:e48240

Moreno DF, Parisi E, Yahya G, Vaggi F, Csikász-Nagy A, Aldea M Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress. Life Sci Alliance 2:e201800277

Ortega P, Gómez-González B, Aguilera A. Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion. Nat Commun 10(1):5178

Rondón AG, Aguilera A. What causes an RNA-DNA hybrid to compromise genome integrity? DNA Repair. doi: 10.1016/j.dnarep.2019.102660.

Rondón AG, Aguilera A. R-Loops as Promoters of Antisense Transcription. Mol Cell 76(4):529-530

Salas-Armenteros I, Barroso SI, Rondón AG, Pérez M, Andújar E, Luna R, Aguilera A. Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability. Cell Rep 28(6):1551-1563.e7

Santamaría R, Therón R, Durán L, García A, González S, Sánchez M, Antequera F. Genome-wide search of nucleosome patterns using visual analytics. Bioinformatics 35: 2185-2192

Tumini E, Herrera-Moyano E, San Martín-Alonso M, Barroso S, Galmarini CM, Aguilera A. The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability. Mol Cancer Res 17(3):773-782

Zapatka M, Pociño-Merino I, Heluani-Gahete H, Bermúdez-López M, Tarrés M, Ibars E, Solé-Soler R, Gutiérrez-Escribano P, Apostolova S, Casas C, Aragon L, Wellinger R, Colomina N, Torres-Rosell J. Sumoylation of Smc5 promotes error-free bypass at damaged replication forks. Cell Reports. 29:3160-3172

Zatreanu D, Han Z, Mitter R, Tumini E, Williams H, Gregersen L, Dirac-Svejstrup AB, Roma S, Stewart A, Aguilera A, Svejstrup JQ. Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability. Mol Cell pii: S1097-2765(19)30592-1