Dr. Francesc Posas
In eukaryotic cells, stress-activated protein kinase (SAPK) pathways play an essential role in intracellular signaling for proper cell adaptation to extracellular stimuli. Cellular stress results in activation of a conserved family of SAPKs, which include the mammalian p38 and the yeast Hog1. We are interested in studying how and by which mechanisms the SAPKs, either p38 in mammals as well as Hog1 in yeast, regulate cellular cell cycle in response to stress.

We aim for the identification of the target on the replication machinery that is controlled by the MAPK (Hog1 or p38) to arrest cell cycle at S phase and understand the role of S phase arrest as adaptative response controlled by SAPKs.

We are interested in the characterization of the changes occurring at ARSs in response to osmotic stress by using ChIP analysis, biochemistry and genetics.

For further information:

Figure 1:
A. Replication lasts longer when cells are stressed in the s-phase.
Activation of the HOG / p38 pathway mediates S phase arrest upon stress
B. Schematic diagram of the effect of the Hog1 SAPK on cell cycle progression.